San Francisco

Your physician

Patrick Sanger, MD, PhD

I am a primary care internist with a PhD in biomedical informatics. I care for a small number of people over a long time, and I limit the practice to ten patients so that each person’s care can be held, examined, and revised by one physician.

I studied architecture before medicine. I still begin the same way: understand the whole structure, then attend to the detail.

Portrait of Patrick Sanger, MD, PhD
  • Board certified in internal medicine and clinical informatics
  • MD/PhD, biomedical informatics, University of Washington
  • Residency, primary care internal medicine, UCSF
  • BA, architecture, Yale

The path

An unusual route to primary care.

Each turn added something I still use.

Architecture and design

I studied architecture at Yale, on the design track, with an emphasis on computer-aided and graphic design. It taught me to see systems whole, and to care how information reaches the person who has to act on it.

Flight

I have been flying since 1996, in gliders, airplanes, and helicopters, and became a helicopter flight instructor in 2004. Aviation is a discipline of checklists, situational awareness, and calm decisions with incomplete information. Medicine asks for the same.

The laboratory

Before medical school I worked in a nutrition and metabolism laboratory at Children’s Hospital Oakland, on a study comparing the effects of Western and plant-based diets on the gut microbiome in mice. My role was data analysis and visualization, and it was my first experience of turning raw measurements into something a clinician could act on.

Medicine and informatics, together

At the University of Washington I completed an MD and a PhD in biomedical and health informatics, supported by an NIH translational science fellowship. My dissertation built a mobile tool that let patients photograph and report on surgical wounds after leaving the hospital, with machine-learning models that predicted infection from those daily assessments.

I also led the development of an electronic surveillance tool that reads the medical record, including free-text notes, to identify catheter-associated urinary tract infections in real time. The hospital’s infection-control team adopted it for routine use.

Residency at UCSF

I completed residency in primary care internal medicine at the University of California, San Francisco, in the Health Systems Leadership pathway: quality improvement, root-cause analysis of medical error, and health-policy work. I was usually the one analyzing and visualizing the data.

Toward a smaller practice

I chose community practice over an academic career, closer to patients and to my own family. After several years as a primary care physician at Palo Alto Medical Foundation, I began a small, longitudinal practice in San Francisco. N of 1 Medicine is its most concentrated form.

Why N of 1

From the average patient to the one in front of me.

For years after residency I practiced strictly by guidelines. They remain essential: they are the best summary we have of what works on average. But no one I care for is an average, and short trials say little about decisions that play out over decades. Waiting for certainty carries its own risks.

N of 1 is the name for how I practice now. I begin with the strongest population evidence, add what is known about mechanism and the newer evidence that has not yet reached the guidelines, and then treat each plan as a careful experiment in one person: explicit, measured, and revised when the response says it should be.

How I practice

Unhurried, and current.

Slow medicine, current evidence

I take the time to understand what matters to you before deciding what to test or treat. I read new research continually and revise my own approach when the evidence warrants it.

You set the course

I often describe it this way: your body is your ship, and you are the captain. I serve as your first mate, bringing expertise, perspective, and navigation, while you determine the course.

When things move quickly

I am particularly experienced with complex, high-acuity, and rapidly evolving health challenges: situations that call for intensive physician involvement, specialist coordination, close follow-through, and repeated revision of the plan.

Informatics as an instrument

I use AI every day for research, programming, and clinical decision support. Its output is working material until I have reviewed it, and I remain accountable for every conclusion. I also oversee information security for the practice.

Areas of focus

Where I spend most of my attention.

  • Complex and rapidly evolving medical challenges
  • Preventive cardiology and lipid management
  • Metabolic health and body composition
  • Hormonal and menopausal health
  • Sleep, strength, fitness, and resilience
  • Evidence review, clinical informatics, and longitudinal data

Training and certification

The record.

Education

Residency, primary care internal medicine, Health Systems Leadership pathway
University of California, San Francisco
2020
MD/PhD, biomedical and health informatics
University of Washington
2017
NIH translational science (TL1) fellowship
Institute of Translational Health Sciences
2012–2013
BA, architecture, design track
Yale University
2004

Certification

Board eligible, clinical lipidology
American Board of Clinical Lipidology
2024
Board certified, clinical informatics
American Board of Preventive Medicine
2022
Board certified, internal medicine
American Board of Internal Medicine
2020
Flight instructor, helicopters
Federal Aviation Administration
2004
Pilot: gliders, airplanes, and helicopters
Federal Aviation Administration
1996

Practice

Founder
N of 1 Medicine, San Francisco
2026
Chief Longevity Doctor
PeakHealth AI
2025–present
Founder
Healthspan.MD
2024–present
Primary care physician
WholeFamily MD, San Francisco
2024–present
Primary care physician
Palo Alto Medical Foundation
2021–2024

Recognition

Magnuson Scholarship
University of Washington School of Medicine
2014–2015
Emerging Inventor of the Year nominee
UW Medicine
2014

Selected publications

Research.

  1. Electronic surveillance for catheter-associated urinary tract infection using natural language processing.

    AMIA Annual Symposium Proceedings, 2017
  2. Diagnosing surgical site infection using wound photography: a scenario-based study.

    Journal of the American College of Surgeons, 2017
  3. A prognostic model of surgical site infection using daily clinical wound assessment.

    Journal of the American College of Surgeons, 2016
  4. A patient-centered system in a provider-centered world: challenges of incorporating post-discharge wound data into practice.

    Journal of the American Medical Informatics Association, 2016
  5. Patient perspectives on post-discharge surgical site infections: towards a patient-centered mobile health solution.

    PLOS ONE, 2014
  6. Design considerations for post-acute care mHealth: patient perspectives.

    AMIA Annual Symposium Proceedings, 2014

Sanger PC is first author on each. Earlier work includes national presentations at AMIA, the Surgical Infection Society, and IDWeek, and UCSF Grand Rounds on the past, present, and future of electronic medical records (2020).

Outside the clinic

At home in San Francisco.

I live in San Francisco with my wife, a naturopathic doctor and nurse practitioner whose training has widened my sense of what helps people heal, and our two daughters.

What the relationship includes

Return to the overview

N of 1 Medicine

One physician.Ten patients.

San Francisco Bay AreaVirtual care possible for patients in California and New York

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